Also Known As
Acetyl Hexapeptide-8 · Acetyl Hexapeptide-3 · AH8
Overview
Argireline is a synthetic hexapeptide used topically for wrinkle reduction. Marketed as "Botox in a bottle". Works by inhibiting SNARE complex formation, reducing muscle contractions similar to botulinum toxin.
Mechanism of Action
Fragment of SNAP-25 protein. Inhibits SNARE complex assembly, reducing neurotransmitter release at neuromuscular junctions. Reduces facial muscle contractions topically.
Quick Reference
Notes
Limited skin penetration (<0.2% after 24h). 17-27% wrinkle reduction in 15-30 days. Large molecular weight (889 Da) limits absorption.
Dosing Protocol
Pharmacokinetics
Administration
Special Instructions
Topical only - apply to clean, dry skin on expression lines (forehead, around eyes). Limited skin penetration (<0.2%). Best results with 10% concentration. Often combined with other cosmetic peptides.
Warnings
Contraindications
Possible Side Effects
Legal & Regulatory
Pregnancy
Molecular Data
No sources available yet.
Related Peptides
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