Also Known As
Proxofim · FOXO4-D-Retro-Inverso
Overview
FOXO4-DRI is a D-retro-inverso peptide that selectively induces apoptosis in senescent cells. Blocks FOXO4-p53 interaction, causing p53 nuclear exclusion and cell death. Pioneering senolytic research compound.
Mechanism of Action
Disrupts FOXO4-p53 protein interaction in senescent cells. Causes p53 nuclear exclusion leading to cell-intrinsic apoptosis. D-amino acids provide enhanced stability and protease resistance.
Quick Reference
Notes
All D-amino acid retro-inverso peptide. 46 amino acids. Expensive. Experimental senolytic - limited human data. Used in longevity research.
Dosing Protocol
Pharmacokinetics
Administration
Reconstitution
Special Instructions
Experimental senolytic - intermittent dosing only (every 3+ weeks). D-retro-inverso modification provides protease resistance. 46 amino acids - expensive. Limited human data.
Warnings
Contraindications
Drug Interactions
Possible Side Effects
Legal & Regulatory
Pregnancy
Molecular Data
No sources available yet.
Related Peptides
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