Also Known As
HN · HNG · Humanin-G
Overview
Humanin is a 24 amino acid peptide encoded by the mitochondrial MT-RNR2 gene. Shows cytoprotective effects against various stressors. Research focuses on Alzheimers, diabetes, and aging.
Mechanism of Action
Binds to IGFBP-3 and BAX, inhibiting apoptosis. Activates STAT3 and ERK pathways. Interacts with formyl peptide receptors.
Quick Reference
Notes
Species-dependent pharmacokinetics. Synthetic analogs (HNG, HNGF6A, Colivelin) have improved stability and potency.
Dosing Protocol
Pharmacokinetics
Administration
Reconstitution
Special Instructions
Short half-life in vivo. Synthetic analogs (HNG, Colivelin) have improved stability. Research compound.
Warnings
Contraindications
Possible Side Effects
Legal & Regulatory
Pregnancy
Molecular Data
No sources available yet.