Under active development. Data is being added and corrected on an hourly basis.

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VIP structure

VIP

Other
Phase 2 Research
45%
Low-Moderate Risk
2/5

Also Known As

Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide

Overview

VIP is a 28 amino acid neuropeptide found throughout the body. It acts as a neurotransmitter and neuromodulator with potent vasodilatory, anti-inflammatory, and immunomodulatory properties. Research focuses on autoimmune conditions, CIRS, and pulmonary hypertension.

Mechanism of Action

Binds VPAC1 and VPAC2 receptors. Increases cAMP. Vasodilator, smooth muscle relaxant. Anti-inflammatory via inhibition of pro-inflammatory cytokines.

Quick Reference

Common Dose 50-200mcg
Frequency 1-3x daily (nasal or subq)
Half-Life ~1-2 minutes
Storage Refrigerate reconstituted. Very short half-life requires frequent dosing or modified delivery.

Notes

Extremely short half-life limits therapeutic use. Nasal spray common for CIRS. Research ongoing for stable analogs.