Also Known As
Elamipretide · Bendavia · MTP-131 · SBT-272
Overview
SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets and concentrates in mitochondria. FDA approved in 2025 for Barth syndrome. Improves mitochondrial function and ATP production.
Mechanism of Action
Binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, reducing oxidative stress, and enhancing ATP synthesis.
Quick Reference
Notes
FDA approved for Barth syndrome (Sept 2025). In clinical trials for heart failure, mitochondrial myopathies, and age-related conditions.
Dosing Protocol
Pharmacokinetics
Administration
Reconstitution
Special Instructions
FDA approved for Barth syndrome. Selectively targets mitochondria. Daily dosing for mitochondrial support.
Warnings
Contraindications
Possible Side Effects
Legal & Regulatory
Pregnancy
Molecular Data
No sources available yet.