Also Known As
Thymosin Beta-4 · Tβ4 · Timbetasin
Overview
TB-500 is a synthetic peptide of the protein thymosin beta-4. Research indicates potential for promoting cell migration, blood vessel growth, and tissue repair.
Mechanism of Action
Upregulates actin, a cell-building protein. Promotes angiogenesis and reduces inflammation by sequestering G-actin monomers, preventing F-actin polymerization, and facilitating cell migration and tissue remodeling.
Quick Reference
Common Dose 2-5mg
Frequency 2x weekly (loading), 1x weekly (maintenance)
Half-Life Extended activity
Storage Refrigerate reconstituted. Store lyophilized at -20°C.
Dosing Protocol
Typical Dose 5 mg
Range 2 - 10 mg
Loading Phase 5 mg × 28 days
Maintenance 2.5 mg weekly
Pharmacokinetics
Half-Life 2.0 hrs
Onset 30 min
Peak 1.0 hrs
Duration 1.0 days
Bioavailability 75%
Primary Route Subcutaneous
Administration
Routes Subcutaneous, Intramuscular
Injection Sites Abdomen, Thigh, Deltoid
Needle Gauge 29-31G
Syringe Type Insulin
Timing Morning, Post-Workout
Reconstitution
Diluent Bacteriostatic Water
Volume 3 mL
Concentration 3333 mcg/mL
Stability 42 days refrigerated
Vial Sizes 5, 10 mg
Special Instructions
Loading phase: 4-8mg/week for first 4 weeks. Maintenance: 2-4mg every 1-2 weeks.
Warnings
May promote tumor growth in cancer
Not FDA approved
Prohibited in sports (WADA S2)
Contraindications
PregnancyBreastfeedingActive Cancer
Possible Side Effects
Injection Site IrritationHeadacheFatigue
Legal & Regulatory
FDA Status Research Only
WADA Status Prohibited in Sport
Schedule S2
Prescription Not Required
Pregnancy
Not Rated
Molecular Data
Formula C212H350N56O78S
Molecular Weight 4963.44 g/mol
Exact Mass 4963.44
Amino Acids 43
Sequence Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
CAS Number 77591-33-4
PubChem CID 16132341